A disgraced fertility doctor runs a clinical trial in which four women give birth to kittens.

When police officer Carter (Aaron Poole) discovers a blood-soaked man limping down a deserted road, he rushes him to a local hospital with a barebones, night shift staff. As cloaked, cult-like figures surround the building, the patients and staff inside start to turn ravenously insane. Trying to protect the survivors, Carter leads them into the depths of the hospital where they discover a gateway to immense evil.

Maya Dolittle, who can talk to animals like her father, is placed on special assignment by the President of the United States of America.